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U.S. Department of Health and Human Services

Final Rules: Food Additives and Color Additives
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Petition(s): FDA action

Direct Food Substances Affirmed as Generally Recognized as Safe; High Fructose Corn Syrup

Docket number (legacy and/or former docket number(s)): (85N-0548)
Subject additive and intended use: amending its regulations for substances that are generally recognized as safe (GRAS) to affirm that high fructose corn syrup (HFCS), prepared from high dextrose equivalent corn starch hydrolysate by partial enzymatic conversion of glucose (dextrose) to fructose utilizing one of several glucose isomerase enzyme preparations, is GRAS as a direct human food ingredient
21 CFR* affected: 184.1372; Insoluble glucose isomerase enzyme preparations
184.1866; High fructose corn syrup
Substance(s)*, (CAS Registry® No.):
  • glucose isomerase, Actinoplanes missouriensis
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  • glucose isomerase, Streptomyces olivaceus
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  • glucose isomerase, Streptomyces olivochromogenes
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  • glucose isomerase, Bacillus coagulans
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  • glucose isomerase, Streptomyces rubiginosus
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  • high fructose corn syrup
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    Federal Register publication history: Nov 7, 1988; 53 FR 44904; Proposed rule
    Aug 23, 1996; 61 FR 43447; Final rule; Effective date: Aug 23, 1996


     

    *Definitions

    • 21 CFR: Title 21 of the Code of Federal Regulations.
    • Substance: The name of the substance listed in the CFR.
    • CAS Registry® No.: Chemical Abstract Service (CAS) Registry Number® for the substance.
    • Petitions (see also Questions and Answers About the Petition Process)
      • FAP: Food Additive Petition
      • CAP: Color Additive Petition
      • GRP: GRAS Affirmation Petition (replaced by GRAS Notification Program in 1998)
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