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U.S. Department of Health and Human Services

GRAS Notices
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GRN No. 1294

Rebaudioside M produced by enzymatic treatment of steviol glycosides purified from the leaves of Stevia rebaudiana (Bertoni) Bertoni

Consult the regulation(s) cited below to see if your substance is authorized for your intended use.
Intended Use: Intended for use as a general-purpose sweetener in foods excluding infant formula and products under the U.S. Department of Agriculture's jurisdiction, at levels determined by current good manufacturing practice.
Basis: Scientific procedures
Notifier: Arzeda Corporation
Notifier Address: 3421 Thorndyke Ave W
Seattle, WA 98119
GRAS Notice (releasable information): GRN 1294 (in PDF) (2.5 MB)
  Part 2: GRN 1294 amendments (in PDF) (840 kB)
Date of closure: Apr 16, 2026
FDA's Letter: FDA has no questions (in PDF) (191 kB)

* Definitions

  • CAS Reg. No. (or other ID): Chemical Abstract Service (CAS) Registry Number® for the substance or a numerical code (other ID) assigned by HFP to those substances that do not have a CAS Registry Number (977nnn-nn-n series).
  • Substance: The name of the additive as recognized by HFP.
  • 21 CFR: The Code of Federal Regulations, Title 21 is the preferred reference to determine the regulatory status of Indirect Food Additives. Substances whose names appear in 21 CFR, parts 175-178 are authorized for specified intended users and conditions of use as stated in the regulation. Note that substances may appear in more than one regulation, or several times in the same regulation.

Note that if a substance is mentioned in 21 CFR parts 175-178 and thus, is listed above, any other citations for the same substance in other sections of 21 CFR dealing with food additives (parts 1-199 inclusive) may also be cited.
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